THE COMPARISON OF THEOPHYLLINE PERMEABILITIES FROM HYDROPHILIC POLYHYDROXYETHYLMETHACRYLATE AND HYDROPHOBIC POLYURETHANE, POLYVINYLCHLORIDEMEMBRANES

Authors
PULAT M
Citation
M. Pulat, THE COMPARISON OF THEOPHYLLINE PERMEABILITIES FROM HYDROPHILIC POLYHYDROXYETHYLMETHACRYLATE AND HYDROPHOBIC POLYURETHANE, POLYVINYLCHLORIDEMEMBRANES, Reactive polymers, 24(1), 1994, pp. 59-63
Citations number
25
Categorie Soggetti
Polymer Sciences","Engineering, Chemical","Chemistry Applied
Journal title
Reactive polymers → ACNP
ISSN journal
09231137
Volume
24
Issue
1
Year of publication
1994
Pages
59 - 63
Database
ISI
SICI code
0923-1137(1994)24:1<59:TCOTPF>2.0.ZU;2-K
Abstract
In this study, the diffusion characteristics of theophylline through p olyurethane (PU), polyvinylchloride (PVC) and polyhydroxyethylmethacry late (PHEMA) membranes were investigated for their usage as oral contr olled-release reservoir systems. PU and PVC membranes were prepared by the solvent-casting method and PHEMA membrane was prepared by bulk po lymerization of 2-hydroxyethylmethacrylate in different thicknesses. D iffusion measurements were performed in simulated gastric fluid and si mulated intestinal fluid during 10 h at 37-degrees-C using a diffusion cell. Permeability coefficients calculated from diffusion experiments were found to be approximately 10 times higher in PHEMA and PU and PV C membranes.