THE SELECTIVE HISTAMINE H-1-RECEPTOR AGONIST 2-(3-TRIFLUOROMETHYLPHENYL)HISTAMINE INCREASES WAKING IN THE RAT

Authors
MONTI JM JANTOS H LESCHKE C ELZ S SCHUNACK W
Citation
Jm. Monti et al., THE SELECTIVE HISTAMINE H-1-RECEPTOR AGONIST 2-(3-TRIFLUOROMETHYLPHENYL)HISTAMINE INCREASES WAKING IN THE RAT, European neuropsychopharmacology, 4(4), 1994, pp. 459-462
Citations number
17
Categorie Soggetti
Neurosciences,"Pharmacology & Pharmacy
Journal title
European neuropsychopharmacology → ACNP
ISSN journal
0924977X
Volume
4
Issue
4
Year of publication
1994
Pages
459 - 462
Database
ISI
SICI code
0924-977X(1994)4:4<459:TSHHA2>2.0.ZU;2-6
Abstract
The effects of the selective histamine H-1-receptor agonist, 2-(3-trif luoromethylphenyl)histamine, were studied in rats implanted with elect rodes for chronic sleep recordings. 2-(3-Trifluoromethylphenyl)histami ne (80-120 mu g) injected into the left lateral ventricle increased wa kefulness, whereas slow wave sleep was reduced. Pretreatment with pyri lamine (2.0 mg/kg) prevented the effects of the H-1-receptor agonist o n wakefulness and slow wave sleep. Our results further support the inv olvement of histamine in the modulation of the waking state.