CONSTRUCTION OF HUMAN Y-CHROMOSOMAL HAPLOTYPES USING A NEW POLYMORPHIC A-TRANSITION TO G-TRANSITION

We report the discovery of a polymorphic A to G transition found on th e human Y chromosome by sequencing Y-specific sequence-tagged sites (S TSs). It shows maximal linkage disequilibrium with a previously descri bed Alu insertional polymorphism. We analyze further an apparently Afr ican Y chromosome which seems to have entered a Mexican Mayan populati on several generations ago. Using the newly discovered transition and the Y-specific polymorphic Alu insertion, we discuss how the chromosom e's haplotype information might be used to answer questions of human o rigins and migrations.