SCATTER FACTOR AND THE C-MET RECEPTOR - A PARADIGM FOR MESENCHYMAL EPITHELIAL INTERACTION

Authors
ROSEN EM NIGAM SK GOLDBERG ID
Citation
Em. Rosen et al., SCATTER FACTOR AND THE C-MET RECEPTOR - A PARADIGM FOR MESENCHYMAL EPITHELIAL INTERACTION, The Journal of cell biology, 127(6), 1994, pp. 1783-1787
Citations number
51
Categorie Soggetti
Cell Biology
Journal title
The Journal of cell biology → ACNP
ISSN journal
00219525
Volume
127
Issue
6
Year of publication
1994
Part
2
Pages
1783 - 1787
Database
ISI
SICI code
0021-9525(1994)127:6<1783:SFATCR>2.0.ZU;2-R
Abstract
Epithelia and mesenchyme interact during various physiologic and patho logic processes. Scatter factor is a mesenchyme-derived cytokine that stimulates motility, proliferation, and morphogenesis of epithelia. Re cent studies suggest that scatter factor and its receptor (c-met) medi ate mesenchyme/epithelia signalling and even interconversion. In this mini-review, we will discuss how scatter factor and c-met may mediate interactions between mesenchyme and epithelia during embryogenesis, or gan repair, and neoplasia.