MOLECULAR CHARACTERIZATION OF NEPHROGENIC DIABETES-INSIPIDUS

Authors
Citation
Nvam. Knoers, MOLECULAR CHARACTERIZATION OF NEPHROGENIC DIABETES-INSIPIDUS, Trends in endocrinology and metabolism, 5(10), 1994, pp. 422-428
Citations number
39
Categorie Soggetti
Endocrynology & Metabolism
ISSN journal
10432760
Volume
5
Issue
10
Year of publication
1994
Pages
422 - 428
Database
ISI
SICI code
1043-2760(1994)5:10<422:MCOND>2.0.ZU;2-V
Abstract
Nephrogenic diabetes insipidus (NDI) is characterized by insensitivity of the distal renal nephron to the antidiuretic effect of the neurohy pophyseal hormone arginine vasopressin. In the last 2 years, two diffe rent genetic defects causing the NDI phenotype have been identified. T he genes involved encode proteins that reside at both ends of the cell ular vasopressin signaling cascade, namely the vasopressin V-2 recepto r and the aquaporin-2 water channel. Analysis of naturally occurring m utations in the V-2 receptor and the aquaporin-2 water channel will fa cilitate the study of structure-function correlates of both proteins, which will lead to substantial progress in elucidating the cellular me chanisms involved in the antidiuretic effect of vasopressin.