The binding of amaranthin, specific for the Gal beta 1,3 GalNAc and Ne
uAc alpha 2,3 Gal beta 1,3 GalNAc sequences, to the photoreceptors of
the monkey retina was investigated using the avidin-biotinylated perox
idase method. Amaranthin bound to the surfaces of both cone and rod ph
otoreceptors. This and previous lectin histochemical studies show that
O-glycoside linked glycoconjugates are present on the surfaces of bot
h cones and rods: Gal beta 1,3 GalNAc and NeuAc a 2,3 Gal beta 1,3 Gal
NAc are the terminal sugars of the glycoconjugates around cones and ro
ds, respectively.