PRECLINICAL STUDIES OF GOSSYPOL IN PROSTATE CARCINOMA

Hormone refractory prostate cancer remains an incurable disease and th e discovery of newer agents with higher cytotoxic activity is required . Gossypol is a phenolic compound isolated from cottonseed oil which h as been shown to have anti-spermatogenic effects. In in vitro studies, gossypol appears to inhibit the growth of rat prostate cancer cell li ne MAT-LyLu and human prostate adenocarcinoma cell lines PC-3, LNCaP a nd DU-145. In vive, gossypol appeared to inhibit tumor growth of subcu taneously implanted MAT-LyLu cells in Copenhagen rats. Gossypol may be an active agent for the treatment of hormone refractory metastatic pr ostate cancer.