C. Hormann et al., LOW-DOSE SUFENTANIL INCREASES CEREBROSPINAL-FLUID PRESSURE IN HUMAN VOLUNTEERS, Journal of neurosurgical anesthesiology, 7(1), 1995, pp. 7-11
Although sufentanil is frequently used in neuroanesthesia, the effect
of the drug on intracranial pressure is still controversial. In our st
udy, we used an invasive measurement technique to study the effects of
0.1 mug/kg-1 sufentanil on mean lumbar cerebrospinal fluid pressure (
CSFP), mean arterial pressure (MAP), cerebral perfusion pressure (CPP)
, central venous pressure (CVP), heart rate (HR), and end-tidal dioxid
e (ETco2) in five human volunteers. After i.v. injection of sufentanil
, mean lumbar CSFP increased from 6 mm Hg to 12 mm Hg (p < 0.05), and
mean CPP decreased from 92 mm Hg to 78 mm Hg (p < 0.05), whereas MAP,
CVP, HR, and ETco2 remained stable. The results of this study clearly
show that even a low dose of sufentanil transiently increases lumbar C
SFP in volunteers with uncompromised intracranial compliance.