PHYSICAL LINKAGE OF THE GENE-CLUSTER CONTAINING THE LCAT GENE TO THE DNA MARKER D16S124 AT HUMAN-CHROMOSOME REGION 16Q22.1

Authors
FRENGEN E BREDE G LARSEN F SKRETTING G PRYDZ H
Citation
E. Frengen et al., PHYSICAL LINKAGE OF THE GENE-CLUSTER CONTAINING THE LCAT GENE TO THE DNA MARKER D16S124 AT HUMAN-CHROMOSOME REGION 16Q22.1, Cytogenetics and cell genetics, 68(3-4), 1995, pp. 194-196
Citations number
16
Categorie Soggetti
Cell Biology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
68
Issue
3-4
Year of publication
1995
Pages
194 - 196
Database
ISI
SICI code
0301-0171(1995)68:3-4<194:PLOTGC>2.0.ZU;2-Z
Abstract
Pulsed-field gel electrophoresis has been used to construct a long-ran ge restriction map spanning more than 900 kb in the q22.1 region of hu man chromosome 16. The gene cluster containing the lecithin:cholestero l acyl transferase (LCAT) gene is located less than 480 kb from the an onymous DNA marker D16S124 in this map. The results suggest three puta tive CpG islands within 125 kb, in addition to the island previously s hown to be located within the gene cluster. This implies a clustering of both genes and CpG islands in this chromosomal region.