TC-99M SULFUR COLLOID DEMONSTRATION OF DIFFUSE PULMONARY INTERSTITIALEXTRAMEDULLARY HEMATOPOIESIS IN A PATIENT WITH MYELOFIBROSIS - A CASE-REPORT AND REVIEW OF THE LITERATURE

A 60-year-old man with a myeloproliferative syndrome and extramedullar y hematopoiesis had progressive respiratory and cardiac insufficiency during the previous 18 months, with advancing interstitial pulmonary d isease on chest x-ray. During analysis of his respiratory disease, res ults of a transbronchial biopsy showed interstitial involvement with i ncreased numbers of megakaryocytes and other panhematopoietic staining elements. Results of a bone marrow scan demonstrated diffuse replacem ent of pulmonary interstitium with bone marrow, as a component of know n ongoing extramedullary hematopoiesis.