To clarify the range of potential etiologies that may contribute to or
ganic brain syndrome in patients receiving systemic opioids for cancer
pain, we describe 15 patients who presented this complication. In 11
cases, concomitant conditions were found that could contribute to the
onset of organic brain syndrome. These data illustrate that multiple c
auses often play a role in the development of mental status changes in
advanced cancer. Opioids are seldom the only causal factor implicated
.