COLLAGEN SHIELDS DELIVERY OF NETILMICIN - A STUDY OF OCULAR PHARMACOKINETICS

Collagen shields have been used as therapeutic contact lenses to promo te corneal epithelial healing and to deliver hydrosoluble drugs. In al bino rabbits, we studied the ocular pharmacokinetics of netilmicin, an aminoglycoside antibiotic, released by a 24-hour collagen shield imme rsed for 10 min in commercially available eye solution of netilmicin, at the standard concentration of 3 mg/ml. The animals were sacrificed after 0.5, 1, 6 and 18 h. The antibiotic concentrations were measured by the microbiological method. The drug levels remained above the MIC for the usual pathogens for 18 h in the cornea and for 6 h in the aque ous humor. In the iris and ciliary body the peak con centration was re ached 1 h after shield application, netilmicin concentration decreased thereafter rapidly. The lens and the vitreous did not appear to be pe rmeated by the drug. In the conjunctiva, drug concentrations were low, showing a negligible lateral diffusion of netilmicin released by shie lds. In conclusion, our findings show, that if the collagen shields ar e used as delivery systems, a very concentrated drug solution is not r equired to obtain high and persistent levels of netilmicin in cornea.