CANDIDA-GLABRATA, CANDIDA-KRUSEI, NON-ALBICANS CANDIDA SPP, AND OTHERFUNGAL ORGANISMS IN A 60-BED NATIONAL CANCER CENTER IN 1989-1993 - NOASSOCIATION WITH THE USE OF FLUCONAZOLE

During the 5-year period 1989-1993, the incidence of Candida krusei, a nd other non-albicans Candida spp., was analyzed in a 60-bed cancer de partment. The frequency of C. krusei, before fluconazole was introduce d into therapeutic protocols in 1990, was 16.5%, and after introductio n of fluconazole into prophylaxis in acute leukemia in 1991, the incid ence of C. krusei was 12.7%. After 3 years of using this drug in thera py and prophylaxis, the incidence of C. krusei in 1993 was 14.8%, what was lower than before this drug was introduced in our country. 97.6% of all isolated fungi were yeasts and only 2.4% were molds. Among yeas ts, the most frequently isolated pathogen was Candida albicans with 64 .3% in 1989 and 74.2% in 1993. The next was C. krusei with 21.2% in 19 92 and 16.5% in 1989, but 14.8% in 1993, and Candida tropicalis and Ca ndida glabrata with 9.03% in 1989 and 2.7% in 1993. Among the molds, A spergillus spp. was the most frequently isolated genus. Analyzing the etiology of mycologically proven fungal infections confirmed by positi ve blood cultures or biopsies, C. albicans and Aspergillus spp. were t he most common causative organisms.