IDENTIFICATION OF AN AMINO-ACID SUBSTITUTION INVOLVED IN THE REDUCTION OF SENSITIVITY OF HIV-1 TO AN INHIBITOR OF VIRAL PROTEINASE

Authors
TURRIZIANI O ANTONELLI G JACOBSEN H MOUS J RIVA E PISTELLO M DIANZANI F
Citation
O. Turriziani et al., IDENTIFICATION OF AN AMINO-ACID SUBSTITUTION INVOLVED IN THE REDUCTION OF SENSITIVITY OF HIV-1 TO AN INHIBITOR OF VIRAL PROTEINASE, Acta virologica, 38(5), 1994, pp. 297-298
Citations number
11
Categorie Soggetti
Virology
Journal title
Acta virologica → ACNP
ISSN journal
0001723X
Volume
38
Issue
5
Year of publication
1994
Pages
297 - 298
Database
ISI
SICI code
0001-723X(1994)38:5<297:IOAASI>2.0.ZU;2-B
Abstract
Clones derived from HIV variants previously characterized as resistant to Ro31-8959, an inhibitor of viral proteinase (PR), were sequenced. Substitution of glycine by valine at position 48 of the PR protein was found. None of the 20 clones derived from wild type HTLV-IIIB contain this mutation. Since such a position is located in a conserved region of PR, it is possible that the substitution can affect the interactio n of the enzyme with the inhibitor.