RADIATION-THERAPY AND CONCURRENT CISPLATIN ADMINISTRATION IN LOCALLY ADVANCED HEAD AND NECK-CANCER - A HELLENIC COOPERATIVE ONCOLOGY GROUP-STUDY

In an attempt to improve Local control of locally advanced head and ne ck cancer, radiation therapy was combined with cisplatin. Forty-eight patients entered into this study. All patients were irradiated with a Co-60 unit and according to the protocol they should receive 70 Gy in the tumor area and 45 Gy in the rest of neck. Cisplatin was administer ed at a dose of 100 mg/m(2) on days 2, 22 and 42. Thirty-seven (80%) p atients received the total radiation dose as initially planned. Thirty -four (72%) patients achieved complete and 5 (10%) partial response. G rade 3-4 toxicities included vomiting (14%), stomatitis (4%), diarrhea (2%), myelotoxicity (14%), hoarseness (4%), dysphagia (30%), weight l oss (32%), nephrotoxicity (4%) and dermatitis (2%). After a median fol low-up of 26 (range, 18-33) months, 16 patients have died. Among the 3 5 complete responders 6 later on relapsed. Median relapse-free surviva l has not yet been reached. Combined radiation therapy and cisplatin a ppears to be a highly active treatment in patients with advanced head and neck cancer as far as primary locoregional response is concerned.