HORMONAL, RENAL, AND METABOLIC ALTERATIONS DURING HYPERTENSION INDUCED BY CHRONIC INHIBITION OF NO IN RATS

Citation
J. Navarro et al., HORMONAL, RENAL, AND METABOLIC ALTERATIONS DURING HYPERTENSION INDUCED BY CHRONIC INHIBITION OF NO IN RATS, American journal of physiology. Regulatory, integrative and comparative physiology, 36(6), 1994, pp. 180001516-180001521
Citations number
27
Categorie Soggetti
Physiology
ISSN journal
03636119
Volume
36
Issue
6
Year of publication
1994
Pages
180001516 - 180001521
Database
ISI
SICI code
0363-6119(1994)36:6<180001516:HRAMAD>2.0.ZU;2-8
Abstract
The evolution of renal excretory function and circulating vasoactive s ystems was studied during progressive increases in blood pressure (BP) induced in rats by oral administration of N-G-nitro-L-arginine methyl ester (L-NAME; 5-30 mg/100 ml) for 5 wk. L-NAME induced a stepped ele vation (P < 0.05) in BP levels without changing creatinine clearance, urine flow, or sodium excretion rate along the study. Reductions (P < 0.05) in plasma renin activity and plasma aldosterone concentration we re found only during treatment with 30 mg/100 ml of L-NAME. Plasma nor epinephrine and epinephrine concentrations were elevated (P < 0.05) in the last week of the study. Plasma concentrations of endothelin-1 and urinary excretion of prostaglandin E(2), 6-ketoprostaglandin F1(alpha ), and thromboxane B-2 were not significantly affected by L-NAME. Simi larly, no changes in plasma concentrations of glucose, insulin, total cholesterol, or triglycerides were observed. In summary, during long-t erm administration of L-NAME, progressive increases in BP levels were observed without changes in either sodium excretion or enhanced circul ating vasoconstrictor activity. Thus, it is likely that inhibition of synthesis of nitric oxide (NO) in the vasculature leads to an imbalanc e between the tonic relaxing action of NO and the influences of vasoco nstrictor agents even when the latter remain at normal levels.