ENHANCED PRODUCTION OF ANTI-METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS (MRSA) SUBSTANCE BY THE MARINE GREEN-ALGA DUNALIELLA PRIMOLECTA UNDER OPTIMUM CULTURE CONDITIONS

The effects of growth phase, culture temperature, aeration and concent rations of NaNO2, phosphorus, NaCl, MgSO4, CaCl2 and Fe-EDTA in the me dium on algal growth, anti-MRSA activity and antibiotic production by the green alga Dunaliella primolecta were investigated. On the basis o f the above results, the production of anti-methicillin-resistant Stap hylococcus aureus (MRSA) substance by this alga under optimum culture conditions was conducted. When D. primolecta was cultured under the op timum conditions, antibiotic production was increased by 2.3-fold, com pared with production under the standard culture conditions, without i nhibition of algal growth.