Se. Robinson et al., MATERNAL AND FETAL BRAIN AND PLASMA-LEVELS OF COCAINE AND BENZOYLECGONINE AFTER ACUTE OR CHRONIC MATERNAL INTRAVENOUS ADMINISTRATION OF COCAINE, The Journal of pharmacology and experimental therapeutics, 271(3), 1994, pp. 1234-1239
The effect of repeated i.v. administration of cocaine HCl (1.5, 3 or 6
mg/kg daily) from gestational day 8 through gestational day 18 was st
udied on maternal and litter parameters in the pregnant female Sprague
-Dawley rat. These doses of cocaine had no significant effect on mater
nal weight gain or nutritional intake and did not significantly affect
litter size. Levels of cocaine and its metabolite benzoylecgonine in
the brain and plasma of the dams and their fetuses were measured on ge
stational day 18 at 1, 5, 20 or 60 min after a single injection or 11
daily i.v. injections of cocaine (6 mg/kg). The shape of the time cour
ses for cocaine differed somewhat between darns and fetuses, with feta
l plasma concentrations of cocaine initially being lower than those of
their dams and then by 5 min becoming equivalent to those of their da
ms. Although plasma concentrations of cocaine soon equilibrated betwee
n darns and fetuses, plasma concentrations of benzoylecgonine did not.
Interestingly, brain concentrations of cocaine did not differ between
dams and fetuses. The most remarkable finding was that the relative d
istribution of cocaine between brain and plasma differed after chronic
vs. acute treatment, with a relative shift in the distribution of coc
aine from plasma to the brain in the fetuses, and, with the exception
of the earliest time point measured, in the dams after repeated dosing
.