AN IMPROVED PROCEDURE FOR THE SYNTHESIS OF 2-METHOXYISOBUTYLISONITRILE - AN EFFICIENT COMPLEXING AGENT FOR TC-99M

Authors
FERROFLORES G RAMIREZGARCIA L LEZAMA J GARCIAGARCIA P TENDILLA JI
Citation
G. Ferroflores et al., AN IMPROVED PROCEDURE FOR THE SYNTHESIS OF 2-METHOXYISOBUTYLISONITRILE - AN EFFICIENT COMPLEXING AGENT FOR TC-99M, Journal of radioanalytical and nuclear chemistry, 188(6), 1994, pp. 409-415
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Analytical","Nuclear Sciences & Tecnology
Journal title
Journal of radioanalytical and nuclear chemistry → ACNP
ISSN journal
02365731
Volume
188
Issue
6
Year of publication
1994
Pages
409 - 415
Database
ISI
SICI code
0236-5731(1994)188:6<409:AIPFTS>2.0.ZU;2-9
Abstract
Tc-99m hexakis(2-methoxyisobutylisonitrile) is a cationic complex usef ul as a myocardial perfusion agent. The synthesis of 2-methoxyisobutyl isonitrile (MIBI) by a modified and improved procedure in a two-step p rocess with an overall yield of 53% is described. The preparation of i ts copper and technetium-99m complexes is also presented.