PREPARATION AND CHARACTERIZATION OF THE T RITIATED NK-1 RECEPTOR ANTAGONIST CP-96.345 OF A HIGH SPECIFIC RADIOACTIVITY

Authors
KASHEVEROV IE ZAITSEV DA UTKIN YN TSETLIN VI
Citation
Ie. Kasheverov et al., PREPARATION AND CHARACTERIZATION OF THE T RITIATED NK-1 RECEPTOR ANTAGONIST CP-96.345 OF A HIGH SPECIFIC RADIOACTIVITY, Bioorganiceskaa himia, 20(11), 1994, pp. 1162-1168
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
20
Issue
11
Year of publication
1994
Pages
1162 - 1168
Database
ISI
SICI code
0132-3423(1994)20:11<1162:PACOTT>2.0.ZU;2-O
Abstract
[H-3]CP-96.345 with the specific radioactivity of 84,2 Ci/mmol has bee n prepared from CP-96.345 by the high-temperature solid state isotopic exchange. The tritiated compound was equipotent with the parent anata gonist in inhibiting the iodinated substance P binding to brain membra nes from various species. Direct binding of [H-3]CP-96.345 was detecte d by radioligand analysis using the striatum-enriched membranes from t he guinea-pig brain.