SYNTHESIS OF FLUORO AND AZIDO DERIVATIVES OF PURINE NUCLEOSIDES FROM NUCLEOSIDES 2',3'-CYCLOSULPHATES

Authors
KOBYLINSKAYA VI SHALAMAY AS GLADKAYA VA MAKITRUK VL KONDRATYUK IV
Citation
Vi. Kobylinskaya et al., SYNTHESIS OF FLUORO AND AZIDO DERIVATIVES OF PURINE NUCLEOSIDES FROM NUCLEOSIDES 2',3'-CYCLOSULPHATES, Bioorganiceskaa himia, 20(11), 1994, pp. 1226-1230
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
20
Issue
11
Year of publication
1994
Pages
1226 - 1230
Database
ISI
SICI code
0132-3423(1994)20:11<1226:SOFAAD>2.0.ZU;2-I
Abstract
2',3'-Cyclosulphate derivatives of inosine and adenosine were synthesi zed by the action of sulphuryl chloride on N,O-benzoyl nucleosides in the presence of triethylamine. Reactions of nucleophilic substitution of the sulphate group led to fluoro and azido derivatives of the nucle osides, which, according to the H-1- and F-19-NMR spectra, are 3'-subs tituted 3'-deoxyxylofuranosides.