EXERCISE PHYSIOLOGY OF WILD AND RANDOM-BRED LABORATORY HOUSE MICE ANDTHEIR RECIPROCAL HYBRIDS

Citation
Mr. Dohm et al., EXERCISE PHYSIOLOGY OF WILD AND RANDOM-BRED LABORATORY HOUSE MICE ANDTHEIR RECIPROCAL HYBRIDS, American journal of physiology. Regulatory, integrative and comparative physiology, 36(4), 1994, pp. 180001098-180001108
Citations number
37
Categorie Soggetti
Physiology
ISSN journal
03636119
Volume
36
Issue
4
Year of publication
1994
Pages
180001098 - 180001108
Database
ISI
SICI code
0363-6119(1994)36:4<180001098:EPOWAR>2.0.ZU;2-N
Abstract
We conducted a ''common garden'' experiment to compare aspects of exer cise physiology and voluntary wheel-running behavior in wild and rando m-bred (i.e., non-inbred) laboratory house mice and their reciprocal c rosses. Analysis of covariance indicated that, after effects of body m ass and other appropriate covariates (e.g., age at testing) were accou nted for, wild (range 2.46-3.30 m/s, n = 12) and hybrid (range 1.69-3. 30 m/s, n = 24) mice exhibited forced maximal sprint running speeds th at averaged similar to 50% higher than those of random-bred laboratory mice (range 1.11-2.12 m/s, n = 19). Wild and hybrid mice also had sig nificantly higher (+ 22%) mass-corrected maximal rates of oxygen consu mption (VO2max) during forced exercise and greater (+ 12%) relative ve ntricle masses than lab mice. Wild and hybrid mice also showed statist ically higher swimming endurance times relative to body mass than lab mice, although these differences were insignificant when body mass was not used as a covariate. No significant differences were found for re lative gastrocnemius muscle mass, liver mass, hematocrit, or blood hem oglobin content. During a 7-day test on voluntary activity wheels, bot h wild and hybrid mice ran significantly more total revolutions (+ 101 %), ran at higher average velocities when they were active (+ 69%), an d exhibited higher maximum revolutions in any single 1-min period (+ 4 1% on the 7th day of testing), but the total number of active 1-min in tervals did not differ significantly among groups. In general, the beh avioral and/or whole organism performance traits showed greater differ ences than the lower-level traits; thus, during the domestication of h ouse mice, behavior may have evolved more rapidly than physiology.