SULFONES DERIVED FROM METHYLTHIOPROPENOIC ACID-AMIDES FROM GLYCOSMIS-ANGUSTIFOLIA

Seven new sulphones derived from methylthiopropenoic acid amides have been isolated as dominant components from the methanolic leaf extract of Glycosmis angustifolia collected in Sri Lanka. All derivatives cont ained substituted phenethylamine moieties with prenyloxy (dambullins) or geranyloxy groups (gerambullins) in the paraposition. Additional ox idation of the geranyl side chain leads to a diol (gerambullindiol) an d to ketones (methylgerambullone and methylisogerambullone). The major component, methyldambullin, exhibited moderate antifungal activity.