SESQUITERPENE LACTONES AND OTHER CONSTITUENTS OF SESELI-VAYREDANUM

Twelve sesquiterpenes, seven phenylpropanoids, two sterols, one triter pene, one diterpene and one polyacetylenic compound were identified fr om the most polar fractions of the hexane extract of the aerial parts of Seseli vayredamum. Twelve of them are new natural products: 1 beta- senecioyloxy- 5 beta H,6 alpha H,7 alpha H,10 alpha Me,11 alpha H-eude sm-3-en-6,12-olide, 1 beta-senecioyloxy-5 beta H,6 alpha H,7 alpha H,1 0 alpha Me,11 alpha H-eudesma-2,4(15)-dien-6,12-olide, 2 alpha-angeloy loxy-5 beta-hydroxy-7 alpha H,10 beta Me-eudesm-3-en-1-one, 8 alpha-an geloyloxy-10 beta-hydroxy-slov-3-en-6,12-olide, 10 beta-hydroxy-8 alph a-senecioyloxy-slov-3-en-6,12-olide, 2-oxo-8 alpha-senecioyloxy-5 beta H,6 alpha H-guai-1(10) 3,7(11)-trien-6,12-olide, 8 beta-angeloyloxy-2 -oxo-5 beta H,6 alpha H-guai-1( 10),3,7(11)-trien-6,12-olide, 2-oxo-8 beta-senecioyloxy-5 beta H,6 alpha H-guai-1(10),3,7(11)-trien-6,12-oli de, 10 beta-acetoxy-8 alpha-angeloyloxy- 3 beta-hydroxy-1 beta H,6 alp ha H,7 alpha H,11 alpha H-guai-4-en-6,12-olide, erythro-1 xy-3',4'-met hylenedioxy-5'-methoxy-1-phenylpopane, xy-3',4'-methylenedioxy-5'-meth oxy-1-phenylpropane and 4'-methylenedioxy-2',5'-dimethoxy-1-phenylprop ane. Their structures were established by spectroscopic methods and ch emical correlations.