SYNTHESIS OF [1.1.1.1]METACYCLOPHANE MACROCYCLE

Authors
RAJCA A PADMAKUMAR R SMITHHISLER DJ DESAI SR ROSS CR STEZOWSKI JJ
Citation
A. Rajca et al., SYNTHESIS OF [1.1.1.1]METACYCLOPHANE MACROCYCLE, Journal of organic chemistry, 59(25), 1994, pp. 7701-7703
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
59
Issue
25
Year of publication
1994
Pages
7701 - 7703
Database
ISI
SICI code
0022-3263(1994)59:25<7701:SO[M>2.0.ZU;2-Y
Abstract
Additions of organodilithium reagents to dialdehydes allow for constru ction of [1.1.1.1]metacyclophane macrocycle in similar to 40% yield in the ring forming step, without resort to standard high dilution techn iques. The present methodology is complementary to the conventional co ndensations leading to phenol- and resorcinol-based cyclotetramers.