INTERFERON-ALPHA-2A THERAPY IN CML - DISAPPEARANCE OF BCR ABL TRANSCRIPT IN A CASE OF LONG-LASTING CONTINUOUS CYTOGENETIC CONVERSION/

Authors
PARDINI S ADDIS M DORE F BONFIGLI S NIEDDU RM GALANELLO R LONGINOTTI M PAU MG
Citation
S. Pardini et al., INTERFERON-ALPHA-2A THERAPY IN CML - DISAPPEARANCE OF BCR ABL TRANSCRIPT IN A CASE OF LONG-LASTING CONTINUOUS CYTOGENETIC CONVERSION/, Haematologica, 79(6), 1994, pp. 540-541
Citations number
10
Categorie Soggetti
Hematology
Journal title
Haematologica → ACNP
ISSN journal
03906078
Volume
79
Issue
6
Year of publication
1994
Pages
540 - 541
Database
ISI
SICI code
0390-6078(1994)79:6<540:ITIC-D>2.0.ZU;2-Y
Abstract
Seventy months after diagnosis, minimal residual disease is undetectab le in a patient with Philadelphia chromosome-positive chronic myelogen ous leukemia (CML) in long-lasting continuous cytogenetic conversion ( CCC), achieved through alpha 2a-interferon (IFN-alpha) therapy. Fluctu ating molecular remission, evaluated with the two-stage reverse transc riptase-polymerase chain reaction (RT-PCR) with nested primers, has pe rsisted for two years at the maximum tolerable dose of IFN alpha (1.5 x 10(6)IU per day).