Obsessive-compulsive disorder is an uncommon psychopathological condit
ion, characterized by a set of disturbing symptoms that usually disrup
ts the ongoing behaviour. A growing body of evidence from genetic, bra
in imaging techniques and psychopharmacological studies links this syn
drome to frontal lobe and basal ganglia dysfunction and to the seroton
in system. In this article we review the most recent studies exploring
the biological, neuropsychological and clinical aspects of obsessive-
compulsive disorder.