SUSCEPTIBILITY OF PSEUDOMONAS-AERUGINOSA ISOLATES TO CEFTAZIDIME IS UNRELATED TO THE EXPRESSION OF THE OUTER-MEMBRANE PROTEIN OPRC

Previously, it has been postulated that the porin OprC facilitates the diffusion of ceftazidime through the outer membrane of Pseudomonas ae ruginosa. To further investigate this claim, the outer membrane protei n (OMP) profiles of 22 ceftazidime-susceptible clinical isolates were analyzed. No correlation was found between MIC values and the level of expression of OprC. Further, OprC was either undetectable or expresse d in reduced amounts in 12 isolates. In contrast, OprF and OprE were p resent in all isolates studied. This study suggests that OprC is dispe nsable for the permeation of ceftazidime through the outer membrane of P. aeruginosa.