THE BIOSYNTHESIS OF ARISTEROMYCIN - CONVERSION OF NEPLANOCIN-A TO ARISTEROMYCIN BY A NOVEL ENZYMATIC REDUCTION

Authors
PARRY RJ JIANG YJ
Citation
Rj. Parry et Yj. Jiang, THE BIOSYNTHESIS OF ARISTEROMYCIN - CONVERSION OF NEPLANOCIN-A TO ARISTEROMYCIN BY A NOVEL ENZYMATIC REDUCTION, Tetrahedron letters, 35(52), 1994, pp. 9665-9668
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
52
Year of publication
1994
Pages
9665 - 9668
Database
ISI
SICI code
0040-4039(1994)35:52<9665:TBOA-C>2.0.ZU;2-7
Abstract
Partially purified cell-free extracts of the aristeromycin producer St reptomyces citricolor have been shown to catalyze the NADPH-dependent reduction of neplanocin A to aristeromycin. Stereochemical studies rev ealed that the reduction proceeds with anti geometry and involves tran sfer of the 4 pro-R hydrogen atom of NADPH to the 6'beta position of a risteromycin.