PREPARATION OF 7-MODIFIED DOCETAXEL ANALOGS USING ELECTROCHEMISTRY

Authors
PULICANI JP BOUCHARD H BOURZAT JD COMMERCON A
Citation
Jp. Pulicani et al., PREPARATION OF 7-MODIFIED DOCETAXEL ANALOGS USING ELECTROCHEMISTRY, Tetrahedron letters, 35(52), 1994, pp. 9709-9712
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
52
Year of publication
1994
Pages
9709 - 9712
Database
ISI
SICI code
0040-4039(1994)35:52<9709:PO7DAU>2.0.ZU;2-2
Abstract
The electrochemical reduction of 7 alpha-iodo docetaxel at E-1.3V vs. SCE in methanol in the presence of lithium chloride and hydrochloric a cid leads predominantly to 7-deoxy-docetaxel 9. When the electroreduct ion is conducted at E-1.7V vs. SCE in the presence of sodium acetate a nd acetic acid, the cyclopropanol-containing taxoid 10 is formed in go od yield. Electrochemical reduction of 7-deoxy-docetaxel at C-10 is al so reported. All these docetaxel analogs retain biological activity.