DIRECT ACCESS TO 2-DEBENZOYL TAXOIDS BY ELECTROCHEMISTRY, SYNTHESIS OF 2-MODIFIED DOCETAXEL ANALOGS

Authors
PULICANI JP BEZARD D BOURZAT JD BOUCHARD H ZUCCO M DEPREZ D COMMERCON A
Citation
Jp. Pulicani et al., DIRECT ACCESS TO 2-DEBENZOYL TAXOIDS BY ELECTROCHEMISTRY, SYNTHESIS OF 2-MODIFIED DOCETAXEL ANALOGS, Tetrahedron letters, 35(52), 1994, pp. 9717-9720
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
52
Year of publication
1994
Pages
9717 - 9720
Database
ISI
SICI code
0040-4039(1994)35:52<9717:DAT2TB>2.0.ZU;2-U
Abstract
A new route to semisynthetic 2-modified docetaxel analogs is described using electrochemical cleavage of the 2-benzoate as the key reaction. Subsequent reacylation at C-2 followed by sequential deprotections af forded the title analogs. Biological results of selected 2-docetaxel a nalogs are presented.