VARIATION OF REACTION CHANNEL IN A FLAVOENZYME MODEL WITH A MODIFIED PYRIMIDINE RING

Authors
OHNO A KUNITOMO J KAWAMOTO T TOMISHIMA M BESSHO K YONEDA F
Citation
A. Ohno et al., VARIATION OF REACTION CHANNEL IN A FLAVOENZYME MODEL WITH A MODIFIED PYRIMIDINE RING, Tetrahedron letters, 35(52), 1994, pp. 9729-9732
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
52
Year of publication
1994
Pages
9729 - 9732
Database
ISI
SICI code
0040-4039(1994)35:52<9729:VORCIA>2.0.ZU;2-P
Abstract
A chiral 5-deazaflavin derivative with 2-hydroxymethylphenyl group at N(3) position of the pyrimidine ring has been synthesized. Oxidized fo rm of the 5-deazaflavin derivative is reduced stereospecifically: the hydroxymethyl group exerts steric inhibition in the absence of Mg2+, w hereas it facilitates the approach of a reducing agent in the presence of Mg2+.