STUDY OF THE DISSOLUTION CHARACTERISTICS OF OXAZEPAM VIA COMPLEXATIONWITH BETA-CYCLODEXTRIN

Complex formation of oxazepam and beta-cyclodextrin in solution was st udied by phase solubility and spectral shift methods. The value of the apparent stability constant, K-c, calculated using these techniques, was 205 and 498 M(-1), respectively. Solid complexes of oxazepam and b eta-CD were prepared using the kneading and spray-drying methods. Thes e complexes led to an improvement in the dissolution rate over free ox azepam, spray-drying being the most efficient technique. These complex es were characterized by differential scanning calorimetry (DSC), scan ning electron microscopy (SEM) and X-ray diffraction.