FORMATION OF FORMALDEHYDE IN POLYETHYLENEGLYCOL AND IN POLOXAMER UNDER STRESS CONDITIONS

Authors
FRONTINI R MIELCK JB
Citation
R. Frontini et Jb. Mielck, FORMATION OF FORMALDEHYDE IN POLYETHYLENEGLYCOL AND IN POLOXAMER UNDER STRESS CONDITIONS, International journal of pharmaceutics, 114(1), 1995, pp. 121-123
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
114
Issue
1
Year of publication
1995
Pages
121 - 123
Database
ISI
SICI code
0378-5173(1995)114:1<121:FOFIPA>2.0.ZU;2-Z
Abstract
Bendroflumethiazide (BFMT) hydrolyses to 5-trifluormethyl 2,4-disulfoa moylaniline (TFSA) and phenylacetaldehyde. In solid dispersions of BFM T in polyethylene glycol 6000 (PEG) and poloxamer 188 (PPEO) an unknow n product was detected, isolated and identified as hydroflumethiazide (HFMT). HFMT was produced by the reaction of TFSA with formaldehyde be ing formed from PEG and from PPEO under stress conditions.