A NEW SYNTHESIS OF SOME 4'-THIO-(D)UNDER-BAR-RIBONUCLEOSIDES AND PRELIMINARY ENZYMATIC EVALUATION

Authors
LEYDIER C BELLON L BARASCUT JL DEYDIER J MAURY G PELICANO H ELALAOUI MA IMBACH JL
Citation
C. Leydier et al., A NEW SYNTHESIS OF SOME 4'-THIO-(D)UNDER-BAR-RIBONUCLEOSIDES AND PRELIMINARY ENZYMATIC EVALUATION, Nucleosides & nucleotides, 13(10), 1994, pp. 2035-2050
Citations number
37
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
10
Year of publication
1994
Pages
2035 - 2050
Database
ISI
SICI code
0732-8311(1994)13:10<2035:ANSOS4>2.0.ZU;2-3
Abstract
A new synthesis of 4'-thioribonucleosides is presented together with t he enzymatic evaluation of the adenosine analogues with respect to ade nosine kinase. The 4-thio-D-ribofuranosyl carbohydrate precursor ($) u nder bar 7 was obtained in good yield from D-ribose and further reacte d with adenine and cytosine to give the a and beta anomers of 4'-thioa denosine and 4'-thiocytidine, respectively. 4'-thio-beta-($) under bar D-adenosine, ($) under bar 12 beta, is a poor substrate for bovine li ver adenosine kinase but does not show substrate inhibition of the enz yme.