ACHIRAL NUCLEOTIDE ANALOGS - 5,5-DISUBSTITUTED PYRIMIDINES RELATED TOBARBITURIC-ACID

Authors
VANVLIET MJ VISSCHER J SCHWARTZ AW
Citation
Mj. Vanvliet et al., ACHIRAL NUCLEOTIDE ANALOGS - 5,5-DISUBSTITUTED PYRIMIDINES RELATED TOBARBITURIC-ACID, Nucleosides & nucleotides, 13(10), 1994, pp. 2113-2124
Citations number
13
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
10
Year of publication
1994
Pages
2113 - 2124
Database
ISI
SICI code
0732-8311(1994)13:10<2113:ANA-5P>2.0.ZU;2-Q
Abstract
Achiral nucleotide analogs are of potential interest in origin of life studies. Four new 5,5-diphosphoethylpyrimidine analogs were prepared by condensation of urea or guanidine with alpha,alpha-di(2- [ethoxy-1- ethoxy]ethyl)malononitrile or alpha,alpha-di(2[ethoxy-1-ethoxy]ethyl)e thyl cyanoacetate respectively, followed by removal of the protecting groups and bisphosphorylation. Oligomers of two potentially complement ary analogs have been prepared. Interactions between these oligomers a ppear to be weak in aqueous solution.