Mj. Vanvliet et al., ACHIRAL NUCLEOTIDE ANALOGS - 5,5-DISUBSTITUTED PYRIMIDINES RELATED TOBARBITURIC-ACID, Nucleosides & nucleotides, 13(10), 1994, pp. 2113-2124
Achiral nucleotide analogs are of potential interest in origin of life
studies. Four new 5,5-diphosphoethylpyrimidine analogs were prepared
by condensation of urea or guanidine with alpha,alpha-di(2- [ethoxy-1-
ethoxy]ethyl)malononitrile or alpha,alpha-di(2[ethoxy-1-ethoxy]ethyl)e
thyl cyanoacetate respectively, followed by removal of the protecting
groups and bisphosphorylation. Oligomers of two potentially complement
ary analogs have been prepared. Interactions between these oligomers a
ppear to be weak in aqueous solution.