SYNTHESIS, BASE-PAIRING PROPERTIES AND NUCLEASE RESISTANCE OF OLIGOTHYMIDYLATE ANALOGS CONTAINING METHOXYPHOSPHORAMIDATE INTERNUCLEOSIDE LINKAGES

Authors
PEYROTTES S VASSEUR JJ IMBACH JL RAYNER B
Citation
S. Peyrottes et al., SYNTHESIS, BASE-PAIRING PROPERTIES AND NUCLEASE RESISTANCE OF OLIGOTHYMIDYLATE ANALOGS CONTAINING METHOXYPHOSPHORAMIDATE INTERNUCLEOSIDE LINKAGES, Nucleosides & nucleotides, 13(10), 1994, pp. 2135-2149
Citations number
35
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
10
Year of publication
1994
Pages
2135 - 2149
Database
ISI
SICI code
0732-8311(1994)13:10<2135:SBPANR>2.0.ZU;2-1
Abstract
A dithymidine N-methoxyphosphoramidate was synthesized and incorporate d into oligothymidylate analogs. The analogs form less stable duplexes with poly dA and poly rA than the corresponding ''all diester'' oligo mer. The instability is more pronounced with poly rA than with poly dA . The analogs were found to be highly resistant to nucleases.