NMR-STUDIES SHOW MONOMERIC 5-FLUOROURIDINE FORMS BASE-PAIRS OF INCREASED STABILITY COMPARED WITH URIDINE IN NONAQUEOUS SOLVENTS

Authors
GMEINER WH ANDERSON J SAHASRABUDHE P
Citation
Wh. Gmeiner et al., NMR-STUDIES SHOW MONOMERIC 5-FLUOROURIDINE FORMS BASE-PAIRS OF INCREASED STABILITY COMPARED WITH URIDINE IN NONAQUEOUS SOLVENTS, Nucleosides & nucleotides, 13(10), 1994, pp. 2329-2344
Citations number
16
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
13
Issue
10
Year of publication
1994
Pages
2329 - 2344
Database
ISI
SICI code
0732-8311(1994)13:10<2329:NSM5FB>2.0.ZU;2-Q
Abstract
The binding constants and geometries for nucleoside base pairs involvi ng 5-fluorouridine (FUr) and adenosine were determined by H-1, C-13, a nd F-19 NMR to better understand how FUr may perturb RNA structure. 5F U:A base pairs are more stable than U:A base pairs.