PROTECTION OF FOCAL ISCHEMIC INFARCTION BY RILMENIDINE IN THE ANIMAL - EVIDENCE THAT INTERACTIONS WITH CENTRAL IMIDAZOLINE RECEPTORS MAY BENEUROPROTECTIVE
Dj. Reis et al., PROTECTION OF FOCAL ISCHEMIC INFARCTION BY RILMENIDINE IN THE ANIMAL - EVIDENCE THAT INTERACTIONS WITH CENTRAL IMIDAZOLINE RECEPTORS MAY BENEUROPROTECTIVE, The American journal of cardiology, 74(13), 1994, pp. 25-30
Rilmenidine and idazoxan reduce the volume of focal ischemic infarctio
ns produced by occlusion of the middle cerebral artery In the rat by 3
3% and 29%, respectively, by;preserving neurons within the ischemic pe
numbra. In contrast, the alpha(2)-selective antagonist SKF-86466 is wi
thout effect. The neuroprotective action of rilmenidine is dose depend
ent a;nd parallels its antihypertensive actions. Neuroprotection canno
t be attributed to changes in cerebral blood flow We conclude that the
neuroprotection produced by rilmenidine is attributable to an interac
tion with imidazoline receptors (IRs). However, tire mechanism of acti
on is not obvious. If it results from an action within the penumbra (d
irect), it is mediated by mitochondrial I-2 receptors on astrocytes, s
ince cortical neurons are devoid of IRs. Neuroprotection might occur b
y selectively stimulating Ca2+ uptake into astrocytes, and thereby red
ucing Ca2+ uptake into neurons. Alternatively, rilmenidine may act ind
irectly to activate pathways in the brain that are neuroprotective. Ne
uroprotection may be a therapeutic target for rilmenidine and allied a
gents that act at central IRs.