De. Biondillo et al., INTERFERON-GAMMA REGULATION OF INTERLEUKIN-6 IN MONOCYTIC CELLS, American journal of physiology. Lung cellular and molecular physiology, 11(5), 1994, pp. 564-568
The regulation of interleukin 6 (IL-6) is dependent on many factors th
at include numerous stimuli such as lipopolysaccharide (LPS), viruses,
and other cytokines. These studies demonstrate the ability of interfe
ron-gamma (IFN-gamma) to significantly enhance IL-6 mRNA and protein p
roduction in LPS-stimulated monocytes and THP-1 cells. IL-6 protein pr
oduction was increased sevenfold in LPS-stimulated cells with the addi
tion of IFN-gamma. IL-6 mRNA production was increased in a dose-depend
ent fashion up to 15-fold in LPS-stimulated cells with the addition of
IFN-gamma. The enhanced production of IL-6 mRNA that occurs with the
addition of IFN-gamma to LPS-stimulated monocytic cells was due to inc
reased transcription of IL-6 mRNA. The ability of IFN-gamma to enhance
IL-6 production may play an important role in many inflammatory proce
sses.