LOW-MOLECULAR-WEIGHT (TUBULAR) PROTEINURIA IS NOT RELATED TO GLYCEMICCONTROL IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS

Early morning urine specimens were obtained from two groups of non-ins ulin dependent diabetic patients and a group (43 subjects) of normal c ontrols. The diabetic patients were divided into two subgroups accordi ng to the degree of diabetic control as judged by their glycosylated h aemoglobin (HbA(1)) levels (well-controlled, 47 subjects; poorly contr olled, 51 subjects), The concentration of the low-molecular-weight enz yme (lysozyme) was determined in each urine specimen and related to th e concentration of creatinine (lysozyme/creatinine). The mean urinary lysozyme concentration was higher in each of the two diabetic groups a s compared with the control group. However, it was not significantly d ifferent between the two diabetic groups. These results suggest that t here is no association between the degree of glycaemic control and tub ular proteinuria.