The impact of including indirect costs of disease (as a result of abse
nce from work, disability and mortality) on outcomes of economic evalu
ations of specific health care programs is analyzed. For eight health
care programs, changes in indirect costs are estimated using the frict
ion cost method, that seeks to estimate the economic losses due to dis
ease or the economic gains of health care programs. The impact of indi
rect costs on outcomes varies considerably across programs. Indirect c
osts tend to play an important role if health care programs produce he
alth effects in the short run, if (short term) absence from work is af
fected considerably and if a significant proportion of the target popu
lation is employed at the moment they benefit from the program. The po
ssible induction of treatment related absence from work and disability
may also be relevant.