A. Barjoseph et al., NEUROPROTECTIVE ACTIVITY OF HU-211, A NOVEL NMDA ANTAGONIST, IN GLOBAL-ISCHEMIA IN GERBILS, Molecular and chemical neuropathology, 23(2-3), 1994, pp. 125-135
HU-211, a nonpsychotropic cannabinoid and a noncompetitive NMDA antago
nist, was tested in a global ischemia model in the Mongolian gerbil. M
ale Mongolian gerbils underwent a 10-min bilateral common carotid arte
ry occlusion. HU-211, administered iv at 4 mg/kg, 30 min postischemia,
induced statistically significant neuroprotection of the CA1 subfield
of the hippocampus. A dose-response study demonstrated an inverted U
curve in which the 4 mg/kg dose induced the best neuroprotection in th
e CA1 subfield of the hippocampus (p < 0.05 ANOVA followed by Duncan's
post-hoc test). The therapeutic window was then investigated, and in
another study, HU-211 4 mg/kg were administered iv at 30, 60, 120, and
180 min postinsult. A statistically significant neuroprotection was d
etected at 30 and 60 min administration postinsult.