POTENT AND SELECTIVE INHIBITORS OF GELATINASE-A .1. HYDROXAMIC ACID-DERIVATIVES

Authors
PORTER JR BEELEY NRA BOYCE BA MASON B MILLICAN A MILLAR K LEONARD J MORPHY JR OCONNELL JP
Citation
Jr. Porter et al., POTENT AND SELECTIVE INHIBITORS OF GELATINASE-A .1. HYDROXAMIC ACID-DERIVATIVES, Bioorganic & medicinal chemistry letters, 4(23), 1994, pp. 2741-2746
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
23
Year of publication
1994
Pages
2741 - 2746
Database
ISI
SICI code
0960-894X(1994)4:23<2741:PASIOG>2.0.ZU;2-E
Abstract
A series of hydroxamic acid derivatives were prepared. By introducing aromatic substituents at the P1' and P3' positions highly potent gelat inase-A inhibitors, which possess a high degree of selectivity over co llagenase and stromelysin, were obtained. These inhibitors may be of t herapeutic value in the control of tumour metastasis.