POTENT AND SELECTIVE INHIBITORS OF GELATINASE-A .2. CARBOXYLIC AND PHOSPHONIC ACID-DERIVATIVES

Authors
MORPHY JR BEELEY NRA BOYCE BA LEONARD J MASON B MILLICAN A MILLAR K OCONNELL JP PORTER J
Citation
Jr. Morphy et al., POTENT AND SELECTIVE INHIBITORS OF GELATINASE-A .2. CARBOXYLIC AND PHOSPHONIC ACID-DERIVATIVES, Bioorganic & medicinal chemistry letters, 4(23), 1994, pp. 2747-2752
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
23
Year of publication
1994
Pages
2747 - 2752
Database
ISI
SICI code
0960-894X(1994)4:23<2747:PASIOG>2.0.ZU;2-8
Abstract
A series of zinc binding groups was introduced into a pseudopeptide se quence containing aromatic groups in the P1' position in order to obta in selective inhibitors of gelatinase-A. Carboxylic acid and phosphoni c acid groups provided the most potent inhibitors