SYNTHESIS AND BIOLOGICAL PROPERTIES OF A NEW SERIES OF ANTI-MRSA BETA-LACTAMS - 2-(THIAZOL-2'-YLTHIO)CARBAPENEMS

Authors
SUNAGAWA M YAMAGA H SHINAGAWA H HOUCHIGAI H SUMITA Y
Citation
M. Sunagawa et al., SYNTHESIS AND BIOLOGICAL PROPERTIES OF A NEW SERIES OF ANTI-MRSA BETA-LACTAMS - 2-(THIAZOL-2'-YLTHIO)CARBAPENEMS, Bioorganic & medicinal chemistry letters, 4(23), 1994, pp. 2793-2798
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
23
Year of publication
1994
Pages
2793 - 2798
Database
ISI
SICI code
0960-894X(1994)4:23<2793:SABPOA>2.0.ZU;2-8
Abstract
Synthesis and biological properties of a new series of Ip-methyl carba penems that have been variously substituted thiazol-2'-ylthio side cha in on C-2 are described. Amongst synthesized compounds, 4'-arylthiazol e derivatives showed potent anti-MRSA activity and the introduction of a quaternary cation was effective to reduce binding to human serum al bumin without affecting the anti-MRSA activity.