1-ALPHA,25(OH)(2) VITAMIN-D-3-REGULATED EXPRESSION OF THE EUKARYOTIC GENOME

1 alpha,25(OH)(2)vitamin-D-3, [1 alpha,25(OH)(2)D-3] is a potent stero id hormone that produces a wide array of biologic effects in a variety of target tissues within the body through ifs ability to modulate gen e transcription of specific target genes. Evidence for transcription r egulation of a specific gene typically includes 1 alpha,25(OH)(2)D-3-i nduced modulation in mRNA levels. Additionally, evidence may include m easurements of transcription and/or the presence of a vitamin D respon se element within the promoter region of the gene. To date, over 50 ge nes have been reported to be transcriptionally regulated by 1 alpha,25 (OH)(2)D-3. We present a current list of these genes and the evidence supporting their inclusion on the list.