In an epidemiologic survey, a marginal status of folic acid, vitamin B
-12, and vitamin B-6 was shown to be associated with hyperhomocysteine
mia. In a case-control study, a low plasma folate concentration was as
sociated with increased coronary heart disease risk. This phenomenon a
ppears to be mediated by folate's effect on homocysteine metabolism. B
oth studies offer further perspectives on homocysteine as an atherogen
ic risk factor.