ASSOCIATION OF CHLAMYDIA-TRACHOMATIS IMMUNOGLOBULIN-GAMMA TITERS WITHDYSTROPHIC PERITONEAL CALCIFICATION, PSAMMOMA BODIES, ADHESIONS, AND HYDROSALPINGES

Objective: To correlate Chlamydia trachomatis immunoglobulin gamma (Ig G) titers with psammoma bodies, dystrophic peritoneal calcification, d egree of calcification, adhesions, and hydrosalpinges. Design: This is a prospective single-blinded histologic analysis of tissue and retros pective analysis of historical laboratory and clinical variables. Sett ing: Tertiary hospital and private practice patient charts. Patients: Sixty consecutive patients with C. trachomatis IgG titers reported on the coding sheets of a previous study for endometriosis. Main Outcome Measures: The histologic slides were reviewed in a blinded fashion for calcification. Previously used data sheets were reviewed for C. trach omatis IgG titers. Historical data, adhesion scores, hystrosalpingogra m findings, and laparoscopic findings were obtained from charts. Resul ts: Dystrophic calcification, psammoma bodies, moderate-to-severe dyst rophic calcification and hydrosalpinges were associated with positive C. trachomatis IgG titers. Conclusion: This study suggests relationshi p of C. trachomatis with dystrophic calcification, psammoma bodies, ad hesions, and hydrosalpinges. This relationship suggests that C. tracho matis IgG titers can be used as a marker to help determine those infer tility patients who might best benefit from hysterosalpingogram or lap aroscopy and in clinical studies of endometriosis, infertility, pain, or ovarian cancer. However, there is no current data to suggest a need for therapy on the basis of a positive C. trachomatis IgG titer or of dystrophic peritoneal calcification.