THE PHARMACOKINETICS OF ONCE-DAILY GENTAMICIN IN NEUTROPENIC ADULTS WITH HEMATOLOGICAL MALIGNANCY

Authors
MACGOWAN AP BEDFORD KA BLUNDELL E BROWN NM HABIB F HOWS J KIRKPATRICK B KORNER RJ SLADE RR WHITE LO REEVES DS
Citation
Ap. Macgowan et al., THE PHARMACOKINETICS OF ONCE-DAILY GENTAMICIN IN NEUTROPENIC ADULTS WITH HEMATOLOGICAL MALIGNANCY, Journal of antimicrobial chemotherapy, 34(5), 1994, pp. 809-812
Citations number
9
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
34
Issue
5
Year of publication
1994
Pages
809 - 812
Database
ISI
SICI code
0305-7453(1994)34:5<809:TPOOGI>2.0.ZU;2-E
Abstract
Seven febrile neutropenic adults with normal renal function were treat ed with intravenous gentamicin 4.5 mg/kg once a day in combination wit h azlocillin. Gentamicin serum concentrations 1, 2, 4, 8, and 24 h aft er a 30 min infusion were 10.9 +/- 0.6, 7.1 +/- 0.4, 4.2 +/- 0.2, 1.8 +/- 0.1 and 0.16 +/- 0.003 mg/L respectively. The pharmacokinetics wer e best described by a triphasic plot including a distribution phase (a bout 1/2 h) and two elimination phases, an early and late.